目录产品 » PIVKA II Antibody (1C5), mAb, Mouse
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PIVKA II (1C5), mAb, Mouse

Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC.
询价
V06701-1

产品概述
Specificity Human PIVKA II
Clone ID 1C5
Epitope 12-28 within PIVKA II
Isotype IgG1 for MAbs 1C5
Subclass IgG1
Host Species Mouse
Antigen Species Human
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产品属性
Conjugation Unconjugated
Production Cultured in vitro under conditions free from animal-derived components
Purification Protein A/G affinity column
Concentration ≥ 2mg/ml
Formulation 50 mM Na-citrate, 150 mM NaCl, pH 7.0, containing 0.03% ProClin 300.
Storage For long term storage, aliquot and store at -25°C~-15°C or below. Avoid repeated freezing and thawing cycles.
Product Stability
Temperature, Time Result for clone 1C5
-80°C, 21 days OK
-20°C, 21 days OK
4°C, 21 days OK
20°C, 21 days OK
37°C, 21 days OK
40°C, 21 days OK
Note GenScript can customize this product per customer's request including product size, buffer components, etc.
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应用指导
Platform Capture Detection
CLIA 1C5 2D7
CLIA 6C4 2D7
CLIA 2D7 6C4
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图例
PIVKA II (1C5), MAb, Mouse

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技术背景
Target Background Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC.
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.