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89 条搜索结果 for GLP Peptide
GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats
Authors: Wijnand J C van der Velden, Florent X Smit, Charlotte B Christiansen, Thor C Møller, Gertrud M Hjortø, Olav Larsen, Sine P Schiellerup, Hans Bräuner-Osborne, Jens J Holst, Bolette Hartmann, Thomas M Frimurer, Mette M Rosenkilde
Journal: ACS Pharmacol Transl Sci
PubMed ID: 33615180
Doi: 10.1021/acsptsci.0c00193
Products & Services: Plasmid DNA Preparation   
A novel oral glucagon-like peptide 1 receptor agonist protects against diabetic cardiomyopathy via alleviating cardiac lipotoxicity induced mitochondria dysfunction
Authors: Peng Qian , Hong Tian , Yongkang Wang , Weisheng Lu , Ying Li , Teng Ma, Xiangdong Gao , Wenbing Yao
Journal: Biochem Pharmacol
PubMed ID: 32860826
Doi: https://doi.org/10.1016/j.bcp.2020.114209
Products & Services: Peptide Services   
Genetic engineering of novel super long-acting Exendin-4 chimeric protein for effective treatment of metabolic and cognitive complications of obesity
Authors: Jong Youl Lee, Taehoon Park, Eunmi Hong, Reeju Amatya, Kyung-Ah Park, Young-Hoon Park, Kyoung Ah Min, Minki Jin, Sumi Lee, Seungmi Hwang, Gu Seob Roh, Meong Cheol Shin
Journal: Biomaterials
PubMed ID: 32736262
Doi: 10.1016/j.biomaterials.2020.120250
Products & Services: Gene Synthesis   
An orally available hypoglycaemic peptide taken up by caveolae transcytosis displays improved hypoglycaemic effects and body weight control in db/db mice
Authors: Weisheng Lu, Hong Tian, Peng Qian, Ying Li, Yongkang Wang, Yang Ge, Wenbo Sai, Xiangdong Gao, Wenbing Yao
Journal: Br J Pharmacol
PubMed ID: 32293707
Doi: 10.1111/bph.15069
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Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis
Authors: Martina Sundqvist, André Holdfeldt, Shane C. Wright, Thor C. Møller, Esther Siaw, Karin Jennbacken, Henrik Franzyk, Michel Bouvier, Claes Dahlgren, Huamei Forsman
Journal: biorxiv
Doi: 10.1101/2020.04.30.070011
Products & Services: Plasmid DNA Preparation   
Rational development of a high-affinity secretin receptor antagonist
Authors: Maoqing Dong, Kaleeckal G Harikumar, Sweta R Raval, Juliana E Milburn, Carolyn Clark, Rafael Alcala-Torano, Juan C Mobarec, Christopher A Reynolds, Giovanna Ghirlanda, Arthur Christopoulos, Denise Wootten, Patrick M Sexton, Laurence J Miller
Journal: Biochem Pharmacol
PubMed ID: 32217097
Doi: 10.1016/j.bcp.2020.113929
Products & Services: Peptide Synthesis   
Degradation of the Incretin Hormone Glucagon-Like Peptide-1 (GLP-1) by Enterococcus faecalis Metalloprotease GelE
Authors: LeValley SL, Tomaro-Duchesneau C, Britton RA
Journal: mSphere
PubMed ID: 32051237
Doi: 10.1128/mSphere.00585-19
Products & Services: Codon Optimization   
Dimerization/oligomerization of the extracellular domain of the GLP-1 receptor and the negative cooperativity in its ligand binding revealed by the improved NanoBiT
Authors: Song X, Yu Y, Shen C, Wang Y, Wang N.
Journal: FASEB J
PubMed ID: 31970836
Products & Services: Recombinant Proteins   
Long-Lasting Exendin-4 Fusion Protein Improves Memory Deficits in High-Fat Diet/Streptozotocin-Induced Diabetic Mice
Authors: Park KA, Jin Z, Lee JY, An HS, Choi EB, Kim KE, Shin HJ, Jeong EA, Min KA, Shin MC, Roh GS.
Journal: Pharmaceutics
PubMed ID: 32079069
Products & Services: Gene Synthesis   
Glucagon-like peptide-1 cleavage product GLP-1(9-36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes
Authors: Jing Huang, Yunhan Liu, Liusiyuan Cheng, Jihong Li, Tangrui Zhang, Gang Zhao, Huinan Zhang
Journal: Eur J Pharmacol
PubMed ID: 32949596
Doi: 10.1016/j.ejphar.2020.173581
Products & Services: Catalog Antibody