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Retrograde transport of neurotrophin receptor TrkB-FL inducedby excitotoxicity regulates Golgi stability and is a target forstroke neuroprotection

Authors: Gema María Esteban-Ortega, Elena Torres-Campos, Margarita Díaz-Guerra

Journal: Cell death & disease

PubMed ID: 40883288

Doi: 10.1038/s41419-025-07990-6

Products & Services: Peptide Synthesis Protein and Antibody Isolation

E. coli-mediated expedient biosynthesis of biotin-labeled ubiquitin probe enables activity-based profiling of deubiquitinases in cytoplasmic and nuclear compartments

Authors: Shuai Peng, Shaowen Wang, Xiaotong Liu, Hongrui Xu, Guoqiang Xu, Jia-bin Li

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2025.111760

Products & Services: Codon Optimization Gene Synthesis PCR Cloning and Subcloning

14-3-3 binding maintains the Parkinson’s associated kinase LRRK2 in an inactive state

Authors: Juliana A Martinez Fiesco, Alexandra Beilina, Astrid Alvarez de la Cruz, Ning Li, Riley D Metcalfe, Mark R Cookson, Ping Zhang

Journal: Nature Communications

PubMed ID: 40764514

Doi: 10.1038/s41467-025-62337-1.

Products & Services: Codon Optimization

A rapid, simple, and economical method for the isolation of ribosomes and translational machinery for structural and functional studies

Authors: Jessey Erath, Danielle Kemper, Elisha Mugo, Alex Jacoby, Elizabeth Valenzuela, Courtney F Jungers, Wandy L Beatty, Yaser Hashem, Marko Jovanovic, Sergej Djuranovic, Slavica Pavlovic Djuranovic

Journal: Nature Communications

PubMed ID: 40764614

Doi: 10.1038/s41467-025-62314-8.

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An Apple Susceptibility-Related LRR Receptor-Like Kinase MdRLKT21 Activates Plant Immunity by Hijacking a Trans-Kingdom Fungal microRNA-Like RNA

Authors: Mingliang Lei, Jian Zhang, Jie Wang, Chengyu Gao, Yanting He, Runze Tian, Hao Feng, Lili Huang

Journal: Advanced Science

PubMed ID: 40755370

Doi: 10.1002/advs.202417426

Identification of distinct epitopes in dipeptidyl peptidase-4 inhibitor-associated bullous pemphigoid

Authors: Shoko Mai https://orcid.org/0000-0001-5468-6851, Yosuke Mai https://orcid.org/0000-0001-6356-7192, Inkin Ujiie https://orcid.org/0000-0002-7931-949X, Kentaro Izumi https://orcid.org/0000-0001-8221-9644, Ken Natsuga https://orcid.org/0000-0003-3865-6366, Wataru Nishie https://orcid.org/0000-0002-0486-9112, and Hideyuki Ujiie

Journal: SCIENCE ADVANCES

PubMed ID: 40749047

Doi: 10.1126/sciadv.adv9423

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High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants

Authors: Mihkel Örd, Matthew J Winters, Mythili S Subbanna, Natàlia de Martín Garrido, Victoria I Cushing, Johanna Kliche, Caroline Benz, Ylva Ivarsson, Basil J Greber, Peter M Pryciak, Norman E Davey

Journal: Nature Communications

PubMed ID: 40817109

Doi: 10.1038/s41467-025-62765-z.

Products & Services: Peptide Synthesis

HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates

Authors: Krystal M Ma, Henry J Sutton, Payal P Pratap, Jon M Steichen, Diane Carnathan, James Quinn, Oleksandr Kalyuzhniy, Alessia Liguori, Sashank Agrawal, Sabyasachi Baboo, Patrick Madden, Christopher A Cottrell, Jordan R Willis, Jeong-Hyun Lee, Elise Landais, Xiaozhen Hu, Parham Ramezani-Rad, Gabriel Ozorowski, Vanessa R Lewis, Jolene K Diedrich, Xiaoya Zhou, Tasha K Altheide, Nicole Phelps, Erik Georgeson, Nushin B Alavi, Danny Lu, Saman Eskandarzadeh, Michael Kubitz, Yumiko Adachi, Tina-Marie Mullen, Murillo Silva, Mariane B Melo, Sunny Himansu, Darrell J Irvine, Dennis R Burton, John R Yates 3rd, James C Paulson, Devin Sok, Ian A Wilson, Guido Silvestri, Andrew B Ward, Shane

Journal: Science immunology

PubMed ID: 40845127

Doi: 10.1126/sciimmunol.adt6660

Products & Services: Recombinant Antibody Expression

DeFrND: detergent-free reconstitution into native nanodiscs with designer membrane scaffold peptides

Authors: Qian Ren, Jing Wang, Vinay Idikuda, Shanwen Zhang, Jeehae Shin, W Grant Ludlam, Luis M Real Hernandez, Sara Zdancewicz, Alex J B Kreutzberger, Hucheng Chang, Volker Kiessling, Lukas K Tamm, Ahmad Jomaa, Ilya Levental, Kirill Martemyanov, Baron Chanda, Huan Bao, Dhanya Thamaraparambil Jayaram, Pranav Sivaram, Pranjal Biswas, Yue Dai, Elizabeth A Sweeny, Dennis J Stuehr

Journal: Nature Communications

PubMed ID: 40858559

Doi: 10.1038/s41467-025-63275-8.

Products & Services: Protein and Antibody Isolation

Discovery of CRISPR-Cas12a clades using a large language model

Authors: Yuanyuan Feng, Junchao Shi, Zhanwei Li, Yongqian Li, Jiaxi Yang, Shisheng Huang, Jinfang Zheng, Wei Han, Yunbo Qiao, Jun Zhang, Qi Liu, Yao Yang, Chunyi Hu, Lina Wu, Xiaokang Zhang, Jin Tang, Xingxu Huang, Peixiang Ma

Journal: Nature Communications

PubMed ID: 40849498

Doi: 10.1038/s41467-025-63160-4.

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