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A conjoined universal helper epitope can unveil antitumor effects of a neoantigen vaccine targeting an MHC class I-restricted neoepitope

Authors: Adam M Swartz, Kendra L Congdon, Smita K Nair, Qi-Jing Li, James E Herndon, Carter M Suryadevara, Katherine A Riccione, Gary E Archer, Pamela K Norberg, Luis A Sanchez-Perez, John H Sampson

Journal: npj Vaccines

PubMed ID: 33462231

Doi: 10.1038/s41541-020-00273-5

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Competition-Based Cell Assay Employing Soluble T Cell Receptors to Assess MHC Class II Antigen Processing and Presentation

Authors: Carley Tasker, Jenny Patel, Vibha Jawa, Jad Maamary

Journal: AAPS J

PubMed ID: 33459871

Doi: 10.1208/s12248-020-00553-x

Products & Services: Protein and Antibody Isolation

Early type I IFN blockade improves the efficacy of viral vaccines

Authors: Nicole Palacio , Tanushree Dangi, Young Rock Chung, Yidan Wang, Juan Luis Loredo-Varela, Zhongyao Zhang, Pablo Penaloza-MacMaster

Journal: J Exp Med

PubMed ID: 32820330

Products & Services: Peptide Library Services

An unbiased approach to defining bona fide cancer neoepitopes that elicit immune-mediated cancer rejection

Authors: Cory A Brennick, Mariam M George, Marmar R Moussa, Adam T Hagymasi, Sahar Al Seesi, Tatiana V Shcheglova, Ryan P Englander, Grant Lj Keller, Jeremy L Balsbaugh, Brian M Baker, Andrea Schietinger, Ion I Mandoiu, Pramod K Srivastava

Journal: J Clin Invest

PubMed ID: 33320837

Doi: 10.1172/JCI142823

Products & Services: Peptide Synthesis

Peptide-MHC Binding Reveals Conserved Allosteric Sites in MHC Class I- and Class II-Restricted T Cell Receptors (TCRs)

Authors: He Y, Agnihotri P, Rangarajan S, Chen Y, Kerzic MC, Ma B, Nussinov R, Mariuzza RA, Orban J

Journal: Journal of molecular biology

PubMed ID: 33157083

Doi: 10.1016/j.jmb.2020.10.031

Products & Services: Gene Synthesis

A TCR-like antibody against a proinsulin-containing fusion peptide ameliorates type 1 diabetes in NOD mice

Authors: Yushi Matsumoto, Kazuki Kishida, Maki Matsumoto, Sumiko Matsuoka, Masako Kohyama, Tadahiro Suenaga, Hisashi Arase

Journal: Biochem Biophys Res Commun

PubMed ID: 33208230

Doi: 10.1016/j.bbrc.2020.11.019

Products & Services: Peptide Synthesis

Repertoire-scale determination of class II MHC peptide binding via yeast display improves antigen prediction

Authors: Rappazzo CG, Huisman BD, Birnbaum ME

Journal: Nature Communications

PubMed ID: 32887877

Doi: 10.1038/s41467-020-18204-2

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Detailed and atypical HLA-E peptide binding motifs revealed by a novel peptide exchange binding assay

Authors: Lucy C Walters, Andrew J McMichael, Geraldine M Gillespie

Journal: Eur J Immunol

PubMed ID: 32716529

Doi: 10.1002/eji.202048719

Products & Services: Gene Synthesis

Cutting Edge: Augmenting Muscle MHC Expression Enhances Systemic Pathogen Control at the Expense of T Cell Exhaustion

Authors: Pack AD,Tarleton RL

Journal: Journal of immunology (Baltimore, Md. : 1950)

PubMed ID: 32591392

Doi: 10.4049/jimmunol.2000218

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The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.

Authors: Alix E,Godlee C,Cerny O,Blundell S,Tocci R,Matthews S,Liu M,Pruneda JN,Swatek KN,Komander D,Sleap T,Holden DW

Journal: Cell Host & Microbe

PubMed ID: 32526160

Doi: 10.1016/j.chom.2020.04.024

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