| Products/Services Used | Details | Operation |
|---|---|---|
| Monoclonal Antibody Services | were plated in 24-well culture plates at 150000 cells per well, 24 h later, the medium was changed and cells were incubated with 40 U/mL mouse IFN (GenScript) and 2 g/mL IFN monoclonal antibodies simultaneously for 3 h. The IFN monoclonal antibody used was InVivoMAb anti-mouse IFN (cat. BE0055, Rat IgG1, | Get A Quote |
The use of immunosuppressive drugs for vitiligo treatment carries a potential risk of increased infection, whereas IFN bispecific antibodies represent an alternative therapeutic strategy. Researchers employing the melanoma/Treg vitiligo mouse model identified a critical role of dermal fibroblasts during the progressive phase of vitiligo. These fibroblasts respond to IFN and recruit CD8 + T cells, a mechanism that also contributes to the bilateral symmetrical depigmentation commonly observed in vitiligo patients. To evaluate the suitability of this model as a platform for developing fibroblast-targeted IFN bispecific antibodies, mice were administered regular injections of IFN monoclonal antibodies. The IFN mono... More
