Diabetic chronic wounds pose a significant clinical challenge due to their complex pathophysiology and limited
treatment options. In this study, a silk fibroin/gelatin (SG) gel incorporated with Mdivi-1 (SG/M) was developed
and applied to chronic diabetic wounds. The SG/M hydrogel significantly enhanced diabetic wound healing
compared to the plain SG hydrogel. This potential therapeutic potential of Mdivi-1 relies on promoting
macrophage polarization toward the M2 phenotype and restoring hyperglycemia-mediated mitochondrial dynamic disorders and dysfunction in both macrophages and human umbilical vein endothelial cells (HUVECs)
under high glucose conditions. Furthermore, Mdivi-1 facilitated mitochond... More
Diabetic chronic wounds pose a significant clinical challenge due to their complex pathophysiology and limited
treatment options. In this study, a silk fibroin/gelatin (SG) gel incorporated with Mdivi-1 (SG/M) was developed
and applied to chronic diabetic wounds. The SG/M hydrogel significantly enhanced diabetic wound healing
compared to the plain SG hydrogel. This potential therapeutic potential of Mdivi-1 relies on promoting
macrophage polarization toward the M2 phenotype and restoring hyperglycemia-mediated mitochondrial dynamic disorders and dysfunction in both macrophages and human umbilical vein endothelial cells (HUVECs)
under high glucose conditions. Furthermore, Mdivi-1 facilitated mitochondrial transfer from macrophages to
HUVECs, which further enhanced mitochondrial function in HUVECs and improved their cellular activity. These
findings not only establish Mdivi-1 as a potential novel therapy but also provide a theoretical foundation for
targeting diabetic complications, underscoring the originality and clinical relevance of this research.
