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Persistent Renin-Angiotensin System Sensitization Months After Body Weight Recovery From Severe Food Restriction in Female Fischer Rats

J Am Heart Assoc. 2020; 
Aline M A de Souza, Hong Ji, Xie Wu, Kathryn Sandberg, Crystal A West
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Molecular Biology Reagents … Reagents. Angiotensin‐[1‐8] and captopril were purchased from Sigma (St. Louis, MO). Isoflurane was purchased from Petterson Veterinary (Greeley, CO). Abz‐Phe‐Arg‐Lys( Dnp)‐Pro‐OH was purchased from GenScript (Piscataway, NJ) … Get A Quote

摘要

Background Prior exposure to periods of severe food restriction (sFR) is associated with increased risk of developing hypertension and cardiovascular disease later in life. Methods and Results To investigate the mechanism of these long-term adverse effects of sFR, 4-month-old female Fischer rats were divided in 2 groups and maintained on a normal diet ad libitum (control) or on an sFR diet with 60% reduction in daily food intake for 2 weeks that resulted in a 15% reduction in body weight. After the 2-week sFR period ended, both groups received normal chow ad libitum for 3 months. Within 2 weeks after refeeding was initiated in the sFR group, body weight was restored to control levels; however, plasma angiote... More

关键词

body weight recovery, calorie restriction, sensitization