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Protease-Activated Receptor-2 Regulates Neuro-Epidermal Communication in Atopic Dermatitis

Front Immunol. 2020; 
Timo Buhl, Akihiko Ikoma, Cordula Kempkes, Ferda Cevikbas, Mathias Sulk, Joerg Buddenkotte, Tasuku Akiyama, Debbie Crumrine, Eric Camerer, Earl Carstens, Michael P Schön, Peter Elias, Shaun R Coughlin, Martin Steinhoff
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Molecular Biology Reagents … Louis, MO, 35 µg in saline), the PAR2/MrgprC11 agonist SLIGRL-NH2 (Quality Controlled Biochemicals, Hopkinton, MA, and GenScript, Piscataway, NJ; 35 µg in saline), or serotonin (Sigma, St. Louis, MO; 3 µg in saline). Intradermal (id) microinjections were made … Get A Quote

摘要

Activation of protease-activated receptor-2 (PAR2) has been implicated in inflammation, pruritus, and skin barrier regulation, all characteristics of atopic dermatitis (AD), as well as Netherton syndrome which has similar characteristics. However, understanding the precise role of PAR2 on neuro-immune communication in AD has been hampered by the lack of appropriate animal models. We used a recently established mouse model with epidermal overexpression of PAR2 (PAR2OE) and littermate WT mice to study the impact of increased PAR2 expression in epidermal cells on spontaneous and house dust mite (HDM)-induced skin inflammation, itch, and barrier dysfunction in AD, and . PAR2OE newborns displayed no overt abnorma... More

关键词

PAR2, atopic dermatitis, dorsal root ganglion, endothelin, house dust mite, neuro-immunology, protease-activated receptor-2