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Chlorzoxazone exhibits neuroprotection against Alzheimer's disease by attenuating neuroinflammation and neurodegeneration in vitro and in vivo

Int Immunopharmacol. 2020; 
Yanyan Bai, Xinshun Ma
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Molecular Biology Reagents … Then, the homogenate was centrifuged at 4 °C, and the supernatant were collected for measurements of soluble Aβ (Genscript, USA) following the manufacturer's protocols. The pellet was sonicated with 5 M tris buffer, which were incubated for 30 min at room temperature … Get A Quote

摘要

Alzheimer's disease (AD), a complex and an age-related brain disease, is induced by the accumulation of amyloid beta (Aβ) and neuroinflammation. Chlorzoxazone (CZ) is a classical FDA-approved drug, and shows anti-inflammatory effects. However, up until now, its regulatory role in AD has not been investigated. Therefore, in this study we attempted to explore if CZ could be an effective therapeutic strategy for AD treatment. At first, the in vitro study was performed to mimic AD using Aβ. We found that Aβ caused p65 nuclear translocation in both primary microglial cells and astrocytes, which were, however, restrained by CZ treatments. Meanwhile, CZ incubation markedly decreased the expression of pro-inflammato... More

关键词

Alzheimer’s disease (AD), Chlorzoxazone (CZ), Glial activation, Neurodegeneration, Neuroinflammation