| Products/Services Used | Details | Operation |
|---|---|---|
| Molecular Biology Reagents | … ID, USA). Poly I:C was purchased from Invivogen (San Diego, CA, USA). HDP was purchased from Genscript (Piscataway Township, NJ, USA) at 90% purity. Ovalbumin was purchased from Sigma-Aldrich. The vaccine diluent … | Get A Quote |
The development of new, effective, and safe vaccines necessarily requires the identification of new adjuvant(s) to enhance the potency and longevity of antigen-specific immune responses. In the present study, we compare the antibody-mediated and cell-mediated immune (CMI) responses within groups of mice vaccinated subcutaneously with ovalbumin (OVA; as an experimental antigen) plus polyphosphazene (an innate immune modulator), Polyinosinic:polycytidylic acid (poly-I:C; (an RNA mimetic) and glycopeptide ARC5 (which is a Toll-like receptor (TLR), TLR2 ligand and PAM3CSK4 analogue) formulated together in a soluble vaccine. We also investigated the effect of a polymeric nanoparticle of ARC4 and ARC7 (which are a no... More
