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Regulation of energy metabolism by combination therapy attenuates cardiac metabolic remodeling in heart failure

Int J Biol Sci. 2020; 
Yuting Huang, Kai Zhang, Miaomiao Jiang, Jingyu Ni, Jingrui Chen, Lan Li, Jie Deng, Yan Zhu, Jingyuan Mao, Xiumei Gao, Guanwei Fan
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摘要

Cardiac metabolic remodeling is recognized as an important hallmark of heart failure (HF), while strategies that target energy metabolism have therapeutic potential in treating HF. Shen-Fu formula (S-F) is a standardized herbal preparation frequently used in clinical practice and is a promising combinatorial therapy for HF-related metabolic remodeling. Herein, we performed an untargeted multi-omics analysis using transcriptomics, proteomics, and metabolomics on HF mice induced by transverse aortic constriction (TAC). Integrated and pathway-driven analyses were used to reveal the therapeutic targets associated with S-F treatment. The cardioprotective effect and potential mechanism of S-F were verified by the res... More

关键词

biomarker, cardiovascular systems, combination therapy, energy metabolism, multi-omics