至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Retinoic acid induces differentiation in neuroblastoma via ROR1 by modulating retinoic acid response elements

Oncol Rep. 2020; 
Abhinav Illendula, Norman Fultang, Bela Peethambaran
Products/Services Used Details Operation
Molecular Biology Reagents … 302-79-4; Cayman Chemical Company) (19,20) dissolved in DMSO and diluted in culture media (final DMSO concentration, <0.1%) for up to 96 h without the addition of new culture media. AGN 193109 (product no … NM_005012; GenScript) … Get A Quote

摘要

Neuroblastoma is the most common inheritable, solid neoplasm in children found under the age of 7 and accounts for approximately 7% of childhood cancers. A common treatment that has been prescribed for over a decade is retinoid therapy [using all‑trans retinoic acid (RA)]. Treatment with this differentiating agent has been revealed to progress the cells from their stem‑cell state to a mature neuronal state gaining classical neuronal characteristics, including the suppression of proliferation. However, the molecular mechanism underlying the action of RA treatment remains to be elucidated. In the present study, a novel mechanism of RA‑induced differentiation via regulation of receptor tyrosine kinase‑like... More

关键词