| Products/Services Used | Details | Operation |
|---|---|---|
| Peptide Synthesis | … 40 kcal mol –1 .(34). The RGD peptide is known to target α v β 6 surface integrins, expressed on HSC-3 cells, increasing nanoparticle uptake by the cancer cells.(35, 36) A custom RGD peptide (RGDRGDRGDRGDPGC) purchased from GenScript USA, Inc … | Get A Quote |
Nanoparticles as potential drug delivery vectors are drawing more attention every day. Here, we used gold nanopspheres (AuNSs) to selectively target the Wnt signaling pathway in human oral squamous cell carcinoma (HSC-3) cells. In a previously conducted study, XAV939, a small inhibiter, was found to strongly regulate the Wnt pathway by inhibiting the tankyrase enzyme and subsequent stabilization of cytoplasmic axin levels. In the present study, conjugating XAV939 molecules to AuNSs is found to enhance its potency by at least 100 times over its free form in killing HSC-3 cancer cells. Additionally, XAV 939 uptake studies have demonstrated an enhanced XAV939 bioconjugate delivery to the targeted cells compared to... More
