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Discovering naturally processed antigenic determinants that confer protective T cell immunity

J Clin Invest. 2013-04-01; 
Pavlo Gilchuk, Charles T Spencer, Stephanie B Conant, Timothy Hill, Jennifer J Gray, Xinnan Niu, Mu Zheng, John J Erickson, Kelli L Boyd, K Jill McAfee, Carla Oseroff, Sine R Hadrup, Jack R Bennink, William Hildebrand, Kathryn M Edwards, James E Crowe, John V Williams, Søren Buus, Alessandro Sette, Ton N M Schumacher, Andrew J Link, Sebastian Joyce
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摘要

CD8+ T cells (TCD8) confer protective immunity against many infectious diseases, suggesting that microbial TCD8 determinants are promising vaccine targets. Nevertheless, current T cell antigen identification approaches do not discern which epitopes drive protective immunity during active infection - information that is critical for the rational design of TCD8-targeted vaccines. We employed a proteomics-based approach for large-scale discovery of naturally processed determinants derived from a complex pathogen, vaccinia virus (VACV), that are presented by the most frequent representatives of four major HLA class I supertypes. Immunologic characterization revealed that many previously unidentified VACV determinan... More

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