Products/Services Used | Details | Operation |
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Catalog Antibody> | … Signaling, 5247), ERG Antibody (Abcam, ab92513), PSA Antibody (Abcam, ab137330), XRCC4 Antibody (Santa cruz, sc-271087), RFC3 Antibody (Santa cruz, sc-390293), FANCC antibody (Epigentek, A62566), THE V5 Tag Antibody (Genscript, A01724); Immunohistochemistry … | Get A Quote |
The dependency of prostate cancer (PCa) growth on androgen receptor (AR) signaling has been harnessed to develop first-line therapies for high-risk localized and metastatic PCa treatment. However, the occurrence of aberrant expression, mutated or splice variants of AR confers resistance to androgen ablation therapy (ADT), radiotherapy or chemotherapy in AR-positive PCa. Therapeutic strategies that effectively inhibit the expression and/or transcriptional activity of full-length AR, mutated AR and AR splice variants have remained elusive. In this study, we report that mithramycin (MTM), an antineoplastic antibiotic, suppresses cell proliferation and exhibits dual inhibitory effects on expression and transcriptio... More