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Ribosomal protein metallopanstimulin-1 impairs multiple myeloma CAG cells growth and inhibits fibroblast growth factor receptor 3.

Clin Lymphoma Myeloma Leuk.. 2011-12; 11(6):490-7

Dai Y, Pierson S, Dudney C, Zeng Y, Macleod V, Shaughnessy JD, Stack BC Jr. 1 Department of Otolaryngology—Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, AR2 Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR

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IntroductionIt was demonstrated that metallopanstimulin-1 (MPS-1, RPS27) inhibited the growth of tumors formed by head and neck squamous cell carcinoma cells and reduced paxillin gene expression.MethodsThe present study examined whether and how MPS-1 affects another type of cancer, multiple myeloma (CAG). Enhanced expression of MPS-1 dramatically inhibited CAG in vitro and in vivo.ResultsOverexpression of MPS-1 resulted in decreased fibroblast growth factor (FGF2) receptor 3 and impaired endogenous MAPK/ErK signaling. MAPK/ErK signaling was not stimulated by adding recombinant FGF2 to myeloma cells overexpressing MPS-1.ConclusionsThese data suggest that MPS-1 suppresses CAG growth and that weakened FGF2 signali... More