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Collective Cell Migration on Artificial Extracellular Matrix Proteins Containing Full-Length Fibronectin Domains.

Adv Mater.. 2010-12;  22(46):5271-5
Eileen Fong, David A. Tirrell. Department of Bioengineering, California Institute of Technology, Pasadena, California 91125, USA.
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摘要

Protein-based biomaterials that promote rapid wound healing are prepared by expression of artificial genes in bacterial cells. Artificial extracellular matrix proteins containing full-length fibronectin domains 9 and 10 exhibit strong α5β1 integrin binding and support rapid spreading, proliferation, and collective migration of fibroblasts.

关键词

wound healing;extracellular matrices;artificial proteins;hybrid materials