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Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells

J Clin Invest. 2020-04; 
Palrasu M, Zaika E, El-Rifai W, Garcia-Buitrago M, Piazuelo MB, Wilson KT, Peek RM Jr, Zaika AI.
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Molecular Biology Reagents Vectors, RNAi, and chemicals. pcDNA3-FLAG-Siva1 expression plasmid was purchased from GenScript (catalog OHu18390D). Get A Quote

摘要

Approximately half of the world's population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori-infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and it... More

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