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Inherited variant in NFκB‐1 promoter is associated with increased risk of IBD in an Algerian population and modulates SOX9 binding

Cancer Reports. 2020; 
Imene Hamadou | Sonia Garritano | Alessandro Romanel, | Dalila Naimi | Talel Hammada | Francesca Demichelis
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Molecular Biology Reagents The genomic sequence corresponding to the region of NFκB1 promoter (hg19 chr4: 103421416-103,422,206) was cloned upstream the luciferase gene into the pGL4.14 vector (Promega, Madison, WI) using CloneEZ PCR Cloning Kit (GenScript) and KpnI and XhoI restriction enzymes. Get A Quote

摘要

Background: The link between inflammation and cancer development was intensively studied in the last decade. To date, few studies explored the association between inflammatory genes and colorectal cancer (CRC) development. Aim: The present study aimed to evaluate the implication of three single nucleotide polymorphisms (SNPs), rs28362491 ins/del −94 ATTG in NFκB1, rs6920220 (G/A) in TNFAIP3, and rs419598 (C/T) in IL1RN, which play a role in inflammation regulation in CRC development. Methods and results: A case-control study was conducted on an Algerian cohort of 358 subjects (147 healthy people, 89 individuals affected by inflammatory bowel disease [IBD], and 122 CRC patients enrolled at the University Hosp... More

关键词

colorectal cancer, inflammation, NFκB, SNPs