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Structural proteins of West Nile virus are a major determinant of infectious particle production and fitness in astrocytes.

J Gen Virol. 2014; 
Hussmann KL, Vandergaast R, Zheng K, Hoover LI, Fredericksen BL.
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Custom Vector Construction … 967–2495 and sequence corresponding to the vector backbone of pA-MAD (5′- CGGCAAGAACTCCGCTGTGGGAGTGGAGTCTAGAAATATTGAAAAAGCTTGGCGTAATCA TGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGC-3′) was synthesized by GenScript and … Get A Quote

摘要

The molecular basis for the increased resistance of astrocytes to a non-neuropathogenic strain of West Nile virus (WNV), WNV-MAD78, compared with the neuropathogenic strain WNV-NY remains unclear. Here, we demonstrated that the reduced susceptibility of astrocytes to WNV-MAD78 is due to a combination of both cellular activities as well as viral determinants. Analyses of the viral particle indicated that astrocyte-derived WNV-MAD78 particles were less infectious than those of WNV-NY. Additionally, inhibition of cellular furin-like proteases increased WNV-MAD78 infectious particle production in astrocytes, suggesting that high levels of furin-like protease activity within these cells acted in a cell- and strain-s... More

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