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Distinct Effects of p19 RNA Silencing Suppressor on Small RNA Mediated Pathways in Plants.

PLoS Pathog. 2016; 
Kontra L,, Csorba T, Tavazza M, Lucioli A, Tavazza R, Moxon S, Tisza V, Medzihradszky A, Turina M, Burgyán J.
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摘要

RNA silencing is one of the main defense mechanisms employed by plants to fight viruses. In change, viruses have evolved silencing suppressor proteins to neutralize antiviral silencing. Since the endogenous and antiviral functions of RNA silencing pathway rely on common components, it was suggested that viral suppressors interfere with endogenous silencing pathway contributing to viral symptom development. In this work, we aimed to understand the effects of the tombusviral p19 suppressor on endogenous and antiviral silencing during genuine virus infection. We showed that ectopically expressed p19 sequesters endogenous small RNAs (sRNAs) in the absence, but not in the presence of virus infection. Our presented d... More

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