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Interferon but not MxB inhibits foamy retroviruses.

Virology. 2016; 
Bähr A, Singer A, Hain A, Vasudevan AA, Schilling M, Reh J, Riess M, Panitz S, Serrano V, Schweizer M, König R, Chanda S, Häussinger D, Kochs G, Lindemann D, Münk C.
Products/Services Used Details Operation
Custom Vector Construction Expression-optimized ORFs for SFVmac (NC_010819), SFVagm (NC_010820), SFVora (AJ544579), SFVmar (GU356395), SFVsqu (GU356394), SFVspm (EU010385) and BFV (NC_001831) were synthesized by Genscript (Piscataway, USA) and subc- loned into the CMV-intron A driven eukaryotic expression vector pczi (Heinkelein et al. Get A Quote

摘要

Foamy viruses (FV) are retroviruses that are widely distributed in primate and non-primate animal species. We tested here FV with capsids of simian and non-simian origin for sensitivity to interferon-β (IFN-β). Our data show significant inhibition of FV by IFN-β early in infection of human HOS and THP-1 but not of HEK293T cells. The post-entry restriction of FV was not mediated by the interferon-induced MxB protein that was recently identified as a capsid-interacting restriction factor targeting Human immunodeficiency virus (HIV) before integration. Neither the ectopic expression of MxA or MxB in HEK293T cells nor the lack of MxB expression in CRISPR/CAS MxB THP-1 knockout cells impacted the infection of the... More

关键词

Foamy viruses; Interferon; Lentiviral vector; MxA; MxB; Restriction factor