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Transferrin receptor mRNA interactions contributing to iron homeostasis.

RNA. 2016; 
Rupani DN, Connell GJ.
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摘要

The transferrin receptor is the primary means of iron importation for most mammalian cells and understanding its regulatory mechanisms is relevant to hematologic, oncologic, and other disorders in which iron homeostasis is perturbed. The 3' UTR of the transferrin receptor mRNA contains an instability element that is protected from degradation during iron depletion through interactions of iron regulatory proteins (IRPs) with five iron-responsive elements (IREs). The structural features required for degradation and the site of IRP binding required for in situ protection remain unclear. An RNA-CLIP strategy is described here that identifies the predominant site of IRP-1 interaction within a nontransformed primary ... More

关键词

endonuclease; iron homeostasis; iron regulatory proteins; iron-responsive elements; transferrin receptor