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miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.

Nat Cell Biol. 2013; 
Zhang Y, Yang P, Sun T, Li D, Xu X, Rui Y, Li C, Chong M, Ibrahim T, Mercatali L, Amadori D, Lu X, Xie D, Li QJ, Wang XF.
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Custom Vector Construction miR-126 and miR-126∗ sponge constructs containing ten repeats of anti- sense miR-126 (5(cid:48) -CGCATTATTAAGTCGGTACGA-3(cid:48) ) or anti-sense miR-126∗ (5(cid:48) -CGCGTACCATTCTAATAATG-3(cid:48) ) were designed following the principles previously described42 , synthesized by GenScript and then cloned into the pMSCVpuro Vector (Clontech). Get A Quote

摘要

The tumour stroma is an active participant during cancer progression. Stromal cells promote tumour progression and metastasis through multiple mechanisms including enhancing tumour invasiveness and angiogenesis, and suppressing immune surveillance. We report here that miR-126/miR-126(*), a microRNA pair derived from a single precursor, independently suppress the sequential recruitment of mesenchymal stem cells and inflammatory monocytes into the tumour stroma to inhibit lung metastasis by breast tumour cells in a mouse xenograft model. miR-126/miR-126(*) directly inhibit stromal cell-derived factor-1 alpha (SDF-1α) expression, and indirectly suppress the expression of chemokine (C-C motif) ligand 2 (Ccl2) by c... More

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