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Genetic variants of the IL22 promoter associate to onset of psoriasis before puberty and increased IL-22 production in T cells.

J Invest Dermatol. 2014; 
Nikamo P, Cheuk S, Lysell J, Enerbäck C, Bergh K, Xu Landén N, Eidsmo L, Ståhle M.
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Custom Vector Construction IL22 promoter with high-risk luciferase construct [rs2227473 (A), INDEL 14 © 2014 The Society for Investigative Dermatology (AY)] or the low-risk luciferase construct [rs2227473 (G), INDEL (--)] genotypes were synthesized and cloned into pGL3 basic vector by GenScript USA Inc. Get A Quote

摘要

Most psoriasis susceptibility genes were identified in cohorts of mixed clinical phenotypes and the exploration of genes in clinical subtypes is scarce. IL-22 has an established role in host defense and in psoriasis skin pathology, reflecting the delicate balance between control of infection and immunopathology. In a case-control study, we compared the genetic association to IL22 in psoriasis onset in patients between 0-9 (n=207), 10-20 (n=394), and 21-40 (n=468) years with healthy controls (n=1,529). Logistic regression analysis revealed association to regulatory elements in the IL22 promoter confined to onset of psoriasis before puberty (odds ratio=1.45, P<0.0007). The associated variants contain putative bin... More

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