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Age dependent course of EAE in Aire-/- mice.

J Neuroimmunol. 2013; 
Aharoni R, Aricha R, Eilam R, From I, Mizrahi K, Arnon R, Souroujon MC, Fuchs S.
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Custom DNA/RNA Oligos Induction and clinical scoring of EAE EAE was induced in female 2 month and 6 month-old mice by the peptide encompassing amino acids 35–55 of myelin oligodendrocyte glycoprotein (MOG), synthesized by Genscript (Piscataway, NJ). Get A Quote

摘要

This study explores the consequences of deficiency in the autoimmune regulator (Aire) on the susceptibility to experimental autoimmune encephalomyelitis (EAE). Increased susceptibility to EAE was found in Aire knockout (KO) compared to wild type (WT) in 6month old mice. In contrast, 2month old Aire KO mice were less susceptible to EAE than WT mice, and this age-related resistance correlated with elevated proportions of T regulatory (Treg) cells in their spleen and brain. Combined with our previous findings in experimental autoimmune myasthenia gravis, we suggest an age-related association between Aire and Treg cells in the susceptibility to autoimmunity.,Copyright © 2013 Elsevier B.V. All rights reserved.

关键词

Autoimmune regulator (Aire); Autoimmunity; Experimental autoimmune encephalomyelitis (EAE); Regulatory T cells (Treg); Susceptibility