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Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells.

J Neuroinflammation. 2014; 
Minter MR, Zhang M, Ates RC, Taylor JM, Crack PJ.
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Custom Vector Construction An optimised nucleotide sequence encoding IFNAR1 mRNA (GenBank: NM_010508) was cloned into a pUC57 vector (GenScript). Get A Quote

摘要

Hypoxic-ischaemic injuries such as stroke and traumatic brain injury exhibit features of a distinct neuro-inflammatory response in the hours and days post-injury. Microglial activation, elevated pro-inflammatory cytokines and macrophage infiltration contribute to core tissue damage and contribute to secondary injury within a region termed the penumbra. Type-1 interferons (IFNs) are a super-family of pleiotropic cytokines that regulate pro-inflammatory gene transcription via the classical Jak/Stat pathway; however their role in hypoxia-ischaemia and central nervous system neuro-inflammation remains unknown. Using an in vitro approach, this study investigated the role of type-1 IFN signalling in an inflammatory s... More

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