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Integrin α3 is involved in non-enveloped hepatitis E virus infection.

Virology. 2019;

Shiota T, Li TC, Nishimura Y, Yoshizaki S, Sugiyama R, Shimojima M, Saijo M, Shimizu H, Suzuki R, Wakita T, Muramatsu M, Ishii K.

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Plasmid DNA Preparation	2) was synthesized and cloned into pUC57 by Genscript (Tokyo, Japan); the resulting plasmid was used as a template for PCR.	Get A Quote

摘要

Hepatitis E virus (HEV) causes acute and fulminant hepatitis worldwide. Although enveloped (e) and non-enveloped (ne) forms of HEV have been discovered, host factors involved in infection, including receptors, remain to be elucidated. Here, we identified integrin α3 (encoded by ITGA3), a protein that binds and responds to the extracellular matrix, as an essential host factor for HEV infection. Integrin α3 expression was lower in four HEV-non-permissive cell subclones than in an HEV-permissive subclone. ITGA3 knockout cells lost HEV permissibility, suggesting that integrin α3 is critical for HEV infection. Stable expression of integrin α3 in an HEV-non-permissive subclone provided permissibility only to infe... More