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Intravenous transfusion of endothelial progenitor cells that overexpress vitamin D receptor inhibits atherosclerosis in apoE-deficient mice.

Biomed Pharmacother. 2016; 
Xiang W, Hu ZL, He XJ, Dang XQ.
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Custom Vector Construction 1/Neo (Genscript, Piscataway, NJ, USA) respectively to generate the final VDR shRNA expression vector. Get A Quote

摘要

Endothelial progenitor cells (EPCs) are widely used for angiogenic therapies, as well as predictive biomarkers to assess cardiovascular disease risk. However, it is unknown that whether overexpressed vitamin D receptor (VDR) in EPCs could help EPCs counteracting atherosclerotic risks. Here, we study intravenous transplantation of genetically modified EPCs over-expressing VDR in regulating endothelial dysfunction and spontaneously arising atherosclerotic plaques of ApoE-deficient mice. Firstly, we found that over-expression of VDR in EPCs could reduce atherosclerotic plaque formation in transplanted ApoE-/- mice. In addition, the concentration of serum HDL-C in ovVDR-EPCs group was much higher than that in contr... More

关键词

Atherosclerosis; Endothelial progenitor cells; Over-expression; Vitamin D receptor