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Biocatalytic Total Synthesis of Ikarugamycin.

Angew Chem Int Ed Engl. 2017; 
Greunke C, Glöckle A, Antosch J, Gulder TA.
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摘要

Nature provides an inexhaustible diversity of small organic molecules with beautiful molecular architectures that have strong and selective inhibitory activities. However, this tremendous biomedical potential often remains inaccessible, as the structural complexity of natural products can render their synthetic preparation extremely challenging. This problem is addressable by harnessing the biocatalytic procedures evolved by nature. In this work, we present an enzymatic total synthesis of ikarugamycin. The use of an iterative PKS/NRPS machinery and two reductases has allowed the construction of 15 carbon-carbon and 2 carbon-nitrogen bonds in a biocatalytic one-pot reaction. By scaling-up this method we demonstr... More

关键词

biocatalysis; enzyme catalysis; ikarugamycin; natural products; total synthesis