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Doxycycline as an inhibitor of p-glycoprotein in the alpaca for the purpose of maintaining avermectins in the CNS during treatment for parelaphostrongylosis.

Vet Parasitol. 2015; 
Agbedanu PN, Anderson KL, Brewer MT, Carlson SA.
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Custom Vector Construction … The consensus sequence is highlighted in gray. 2.2. Heterologous expression of the alpaca gene encoding PGP. The gene encoding the full-length alpaca PGP cDNA was synthesized (GenScript) and cloned into the eukaryotic expression vector pcDNA3.3 (Invitrogen) … Get A Quote

摘要

Meningeal worms (Parelaphostrongylus tenuis) are a common malady of alpacas, often refractory to conventional treatments. Ivermectin is a very effective anthelmintic used against a variety of parasites but this drug is not consistently effective against alpaca meningeal worms once the parasite has gained access to the CNS, even if used in a protracted treatment protocol. Ivermectin is not effective against clinical cases of P. tenuis, raising the possibility that the drug is not sustained at therapeutic concentrations in the central nervous system (CNS). A specific protein (designated as p-glycoprotein (PGP)) effluxes ivermectin from the brain at the blood-brain barrier, thus hampering the maintenance of therap... More

关键词

Alpaca; Avermectin; p-Glycoprotein