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Study of NGEP expression pattern in cancerous tissues provides novel insights into prognostic marker in prostate cancer.

Biomark Med. 2015; 
Mohsenzadegan M, Shekarabi M, Madjd Z, Asgari M, Abolhasani M, Tajik N, Farajollahi MM.
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Peptide Synthesis … Preparation of conjugates. Peptide 1 and 2 were synthesized by the GenScript Co., Ltd (USA Inc.) with approximate purity of 98%. These peptides were conjugated to bovine serum albumin (Sigma, MO, USA) used as immunogens … Get A Quote

摘要

The aim of this study was to produce a novel polyclonal antibody against extracellular domain of NGEP protein and explore its role in prognosis of prostate cancer.,Polyclonal antibodies against two peptides (NGEP-p1 and NGEP-p2) derived extracellular domains of NGEP were prepared and the intensity and distribution of NGEP expression analyzed in large series of prostate tissue specimens.,We found a significant inverse correlation between NGEP expression and prognostic features such as Gleason score, pathologic tumor stage and prostate-specific antigen level using anti-NGEP-p2 antibody.,The results indicate that the high level of expression could be associated with good prognosis in prostate cancer. However, addi... More

关键词

NGEP; anti-peptide antibody; prognostic factors; prostate cancer