Plasma membrane Ca-ATPase (PMCA) is the most sensitive cellular calcium detector. It exists in four main isoforms (PMCA1-4)， among which PMCA2 and PMCA3 are considered as fast-acting neuron-specific forms. In the brain， PMCA function declines progressively during aging; thereby impaired calcium homeostasis may contribute to some neurodegenerative diseases. These destructive processes can be propagated by proinflammatory chemokines， including chemokine CCL5， which causes phospholipase C-mediated liberation of Ca from endoplasmic reticulum by IP-gated channels.
Plasma membrane Ca-ATPase (PMCA) is the most sensitive cellular calcium detector. It exists in four main isoforms (PMCA1-4)， among which PMCA2 and PMCA3 are considered as fast-acting neuron-specific forms. In the brain， PMCA function declines progressively during aging; thereby impaired calcium homeostasis may contribute to some neurodegenerative diseases. These destructive processes can be propagated by proinflammatory chemokines， including chemokine CCL5， which causes phospholipase C-mediated liberation of Ca from endoplasmic reticulum by IP-gated channels.
