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Structural and mechanistic insights into EchAMP: A antimicrobial protein from the Echidna milk.

Biochim Biophys Acta Biomembr. 2019; 
KumarAlok,ParveenSadiya,SharmaIsha,PathakHimani,DeshmukhMandar V,SharpJulie A,KumarSa
Products/Services Used Details Operation
Gene Synthesis . The codon-optimized EchAMP DNA sequence was procured from M/s GenScript Corporation and was verified by aligning the translated amino acid sequence obtained following sequencing with the amino acid sequence of the native protein. Get A Quote

摘要

Antibiotic resistance is a problem that necessitates the identification of new antimicrobial molecules. Milk is known to have molecules with antimicrobial properties (AMPs). Echidna Antimicrobial Protein (EchAMP) is one such lactation specific AMP exclusively found in the milk of Echidna, an egg-laying mammal geographically restricted to Australia and New Guinea. Previous studies established that EchAMP exhibits substantial bacteriostatic activity against multiple bacterial genera. However, the subsequent structural and functional studies were hindered due to the unavailability of pure protein.

关键词

Antimicrobial proteins,EchAMP,Echidna,Intrinsically disordered protein,Milk,Monotr