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Improved serological detection of rheumatoid arthritis: a highly antigenic mimotope of carbonic anhydrase III selected in a murine model by phage display.

Arthritis Res. Ther.. 2015;

AraujoGalber Rodrigues，VazEmília Rezende，FujimuraPatricia Tiemi，FonsecaJoão Eurico，de LimaLucélia Maria，CanhãoHelena，VenturiniGabriela，CardozoKarina Helena Morais，CarvalhoValdemir Melechco，NapimogaMarcelo Henrique，GoulartLuiz Ricardo，GonçalvesJoão，Ueira-VieiraCa

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Peptide Synthesis	Peptide design and synthesis After bioinformatic analysis of the selected clones , the M12 peptide sequence was designed and chemically synthesized by GenScript USA Inc.	Get A Quote

摘要

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects around 1% of the human population worldwide. RA diagnosis can be difficult as there is no definitive test for its detection. Therefore， the aim of this study was to identify biomarkers that could be used for RA diagnosis.