至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Porcine Reproductive and Respiratory Syndrome Virus nsp11 Antagonizes Type I Interferon Signaling by Targeting IRF9.

J. Virol.. 2019; 
WangDang,ChenJiyao,YuChaoliang,ZhuXinyu,XuShangen,FangLiurong,XiaoSh
Products/Services Used Details Operation
Molecular Biology Reagents The RNA substrate (5= -6-carboxyfluorescein-dA-rU-dA-dA-6-carboxy- N,N,N,N-tetramethylrhodamine-3=) was purchased from Nanjing GenScript Company. Get A Quote

摘要

Porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus from the order that causes reproductive failure and respiratory disease in pigs and poses a constant threat to the global pig industry. The PRRSV-encoded nonstructural protein 11 (nsp11) is a nidovirus-specific endoribonuclease (NendoU) that is conserved throughout the and families. Previously, our research and that of others demonstrated that PRRSV nsp11 inhibits type I interferon (IFN) production through NendoU activity-dependent mechanisms. Here, we found that PRRSV nsp11 also inhibited IFN-stimulated response element (ISRE) promoter activity and subsequent transcription of IFN-stimulated genes (ISGs). Detailed analysis show... More

关键词

interferon regulatory factor 9,nidovirus-specific endoribonuclease,porcine reproductive and respiratory syndrome virus,type I IFN signa