Hypovascularization of cervical tumors， coupled with intrinsic and acquired drug resistance， has contributed to marginal therapeutic outcomes by hindering chemotherapeutic transport and efficacy. Recently， the heterogeneous penetration and distribution of cell penetrating peptide (CPP， here MPG) and polyethylene glycol (PEG) modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were evaluated as a function of tumor type and morphology in cervical cancer spheroids modeling hypovascularized tumor nodules. Building upon this work， this study investigates the efficacy imparted by surface-modified Doxorubicin-loaded NPs transported into hypovascularized tissue.
Hypovascularization of cervical tumors， coupled with intrinsic and acquired drug resistance， has contributed to marginal therapeutic outcomes by hindering chemotherapeutic transport and efficacy. Recently， the heterogeneous penetration and distribution of cell penetrating peptide (CPP， here MPG) and polyethylene glycol (PEG) modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were evaluated as a function of tumor type and morphology in cervical cancer spheroids modeling hypovascularized tumor nodules. Building upon this work， this study investigates the efficacy imparted by surface-modified Doxorubicin-loaded NPs transported into hypovascularized tissue.
