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Natural Product Glycosylation: Biocatalytic Synthesis of Quercetin-3,4'-O-diglucoside.

Appl. Biochem. Biotechnol.. 2019; 
SunPing,CaiRuxin,ChenLiangliang,LiYan,JiaHonghua,YanMing,ChenKe
Products/Services Used Details Operation
Custom Vector Construction coli expres- sion vector pRSFDuet-1 (Novagen, Madison, WI, USA) by GenScript (Nanjing, China). Get A Quote

摘要

Flavonoids have gained much attention for their proposed positive effects for human health. Glycosylation is a significant method for the structural modification of various flavanols, resulting in glycosides with increased solubility, stability, and bioavailability compared with the corresponding aglycone. Natural product glycosylation by using enzymes has emerged as a topic of interest as it offers a sustainable and economical alternative source so as to address supply scalability limitations associated with plant-based production. Quercetin-3,4'-O-diglucoside, as one of the major but trace bioactive flavonoids in onion (Allium cepa), is superior or at least equal to quercetin aglycone in its bioav... More

关键词

Glycosylation,Quercetin,Quercetin-3,4′-O-diglucoside,Sucrose synthase,UDP-glycosyltransfer