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Oral and intravenous transmission of α-synuclein fibrils to mice.

Acta Neuropathol. 2019; 
Lohmann Stephanie,Bernis Maria E,Tachu Babila J,Ziemski Alexandra,Grigoletto Jessica,Tamgüney Gült
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Molecular Biology Reagents The ToxinSensor Chromogenic LAL Endotoxin Assay Kit (Genscript) was used according to the manufacturers instructions to verify that the endotoxin levels in our fbril preparations were low (>0.01 EU/mL). Get A Quote

摘要

Parkinson's disease and related disorders are neuropathologically characterized by cellular deposits of misfolded and aggregated α-synuclein in the CNS. Disease-associated α-synuclein adopts a conformation that causes it to form oligomers and fibrils, which have reduced solubility, become hyperphosphorylated, and contribute to the spatiotemporal spreading of pathology in the CNS. The infectious properties of disease-associated α-synuclein, e.g., by which peripheral route and with which efficiency it can be transmitted, are not fully understood. Here, we investigated the potential of α-synuclein fibrils to induce neurological disease in TgM83 mice expressing the A53T mutant of human α-synuclei... More

关键词

Infection,Parkinson’s disease,Peripheral,Synucleinop