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Structure and specificity of a permissive bacterial C-prenyltransferase.

Nat. Chem. Biol.. 2017; 
Elshahawi Sherif I，Cao Hongnan，Shaaban Khaled A，Ponomareva Larissa V，Subramanian Thangaiah，Farman Mark L，Spielmann H Peter，Phillips George N，Thorson Jon S，Singh Shan
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Gene Synthesis and bacterial PTs were constructed in a similar fashion from synthetic genes (GenScript); Supplementary Get A Quote

摘要

This study highlights the biochemical and structural characterization of the L-tryptophan C6 C-prenyltransferase (C-PT) PriB from Streptomyces sp. RM-5-8. PriB was found to be uniquely permissive to a diverse array of prenyl donors and acceptors including daptomycin. Two additional PTs also produced novel prenylated daptomycins with improved antibacterial activities over the parent drug.

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