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Transcription factor networks in aged na?ve CD4 T cells bias lineage differentiation.

Aging Cell. 2019; 
Hu Bin,Li Guangjin,Ye Zhongde,Gustafson Claire E,Tian Lu,Weyand Cornelia M,Goronzy J?
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Molecular Biology Reagents . siRNA were purchased from Dharmacon Inc . and plasmids were from Genscript . 4.3 | Flow cytometry Get A Quote

摘要

With reduced?thymic activity, the population of na?ve T cells in humans is maintained by homeostatic proliferation throughout adult life. In young adults, na?ve CD4 T cells have enormous proliferative potential and plasticity to differentiate into different lineages. Here, we explored whether na?ve CD4 T-cell aging is associated with a partial loss of this unbiased multipotency. We find that na?ve CD4 T cells from older individuals have developed a propensity to develop into TH9 cells. Two major mechanisms contribute to this predisposition. First, responsiveness to transforming growth factor β (TGFβ) stimulation is enhanced with age due to an upregulation of the TGFβR3 receptor that results in increa... More

关键词

T-cell lineage differentiation,aging,immunosenescence,interleukin 9,multipotency,transforming growth facto