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Transthyretin Exerts Pro-Apoptotic Effects in Human Retinal Microvascular Endothelial Cells Through a GRP78-Dependent Pathway in Diabetic Retinopathy.

Cell. Physiol. Biochem.. 2017;

Shao Jun，Yin Ying，Yin Xiaowen，Ji Li，Xin Yu，Zou Jian，Yao

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Molecular Biology Reagents	.... ThermoFisher Scientific (Rockford, IL, USA). CNBr-activated Removal kit was from GenScript (Piscataway, NJ.... in an Amicon ToxinEraserTM Endotoxin Removal kit from GenScript. The resulting samples were subjected	Get A Quote

摘要

Diabetic retinopathy (DR) is one of the main causes of blindness in the world. Our previous study showed that transthyretin (TTR) regulates key genes in the Tie2 pathway and inhibits the development of neovascularization in DR， but the mechanism is still unclear. Here， we investigated how TTR affects the progression of neovascularization in DR.