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NIDO, AMOP and vWD domains of MUC4 play synergic role in MUC4 mediated signaling.

Oncotarget. 2017; 
Zhu Yi,Zhang Jing-Jing,Peng Yun-Peng,Liu Xian,Xie Kun-Ling,Tang Jie,Jiang Kui-Rong,Gao Wen-Tao,Tian Lei,Zhang Kai,Xu Ze-Kuan,Mia
Products/Services Used Details Operation
Custom Vector Construction . These target sequences were synthesized and cloned in a pUC57vector (GenScript). 2) The series Get A Quote

摘要

MUC4 mucin is well known as an important potential target to overcome pancreatic cancer. Three unique domains (NIDO, AMOP, and vWD) with unclear roles only present in MUC4 but are not found in other membrane-bound mucins. Our previous studies first reported that its splice variant, MUC4/Y can be a model of MUC4 (MUC4 gene fragment is more than 30KB, too huge to clone and eukaryotic express) in pancreatic cancer. More importantly, based on MUC4/Y with the appropriate length of gene sequence, it is easy to construct the unique domain-lacking models of MUC4/Y (MUC4) for research. The present study focuses on investigation of the respective role of the unique NIDO, AMOP, and vWD domain or their syne... More

关键词

AMOP,MUC4/Y,NIDO,synergy