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Combination of inductive effect of lipopolysaccharide and in situ mechanical conditioning for forming an autologous vascular graft in vivo.

Sci Rep. 2019-07; 
ChenChao-Lin,GuoHow-Ran,WangYing-Jan,ChangHong-Tai,PanChui-Yi,Tuan-MuHo-Yi,LinHsiu-Chuan,ChenChao-Yi,HuJin
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Molecular Biology Reagents … Quantification of lipopolysaccharide in the whole blood scaffold. We measured the effective LPS amount in the fabricated LPS-whole blood scaffold using ToxinSensor chromogenic LAL endotoxin assay kit (GenScript, China) … Get A Quote

摘要

Autologous vascular grafts have the advantages of better biocompatibility and prognosis. However, previous studies that implanted bare polymer tubes in animals to grow autologous tubular tissues were limited by their poor yield rates and stability. To enhance the yield rate of the tubular tissue, we employed a design with the addition of overlaid autologous whole blood scaffold containing lipopolysaccharides (LPS). Furthermore, we applied in vivo dynamic mechanical stimuli through cyclically inflatable silicone tube to improve the mechanical properties of the harvested tissues. The effectiveness of the modification was examined by implanting the tubes in the peritoneal cavity of rats. A group without mech... More

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