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Schistosoma japonicum extracellular vesicle miRNA cargo regulates host macrophage functions facilitating parasitism.

PLoS Pathog. 2019-06; 
LiuJuntao,ZhuLihui,WangJianbin,QiuLin,ChenYongjun,DavisRichard E,ChengGuo
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Molecular Biology Reagents The endotoxin activity of isolated EVs was determined using ToxinSensor Chromogenic LAL Endotoxin Assay Kit according to the manufacturer’s instructions (GenScript, Nanjiang, China). Get A Quote

摘要

Schistosome infection persists for decades. Parasites are in close contact with host peripheral blood immune cells, yet little is known about the regulatory interactions between parasites and these immune cells. Here, we report that extracellular vesicles (EVs) released from Schistosoma japonicum are taken up primarily by macrophages and other host peripheral blood immune cells and their miRNA cargo transferred into recipient cells. Uptake of S. japonicum EV miR-125b and bantam miRNAs into host cells increased macrophage proliferation and TNF-α production by regulating the corresponding targets including Pros1, Fam212b, and Clmp. Mice infected with S. japonicum exhibit an increased population of monocy... More

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