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Progress toward a universal H5N1 vaccine: a recombinant modified vaccinia virus Ankara-expressing trivalent hemagglutinin vaccine.

PLoS ONE. 2014; 
PrabakaranMookkan，LeyrerSonja，HeFang，AuerSebastian，KumarSubaschandrabose R，KindsmuellerKathrin，MytleNutan，SchneiderJoerg，LockhartStephen，KwangJ
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Gene Synthesis … The hemagglutinin (HA) and neuraminidase (NA) genes of H5N1 viruses from clades 0, 1, 2, 4, 7 and 9 (indicated by RG-H5N1 in Table 1) were synthesized (GenScript, USA) based on the sequence from the NCBI Influenza database … Get A Quote

摘要

The rapid evolution of new sublineages of H5N1 influenza poses the greatest challenge in control of H5N1 infection by currently existing vaccines. To overcome this， an MVAtor vector expressing three H5HA antigens A/Vietnam/1203/04， A/Indonesia/669/06 and A/Anhui/01/05 (MVAtor-tri-HA vector) was developed to elicit broad cross-protection against diverse clades by covering amino acid variations in the major neutralizing epitopes of HA among H5N1 subtypes.

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