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Adenovirus-mediated delivery of interferon-γ gene inhibits the growth of nasopharyngeal carcinoma.

J Transl Med. 2012;

LiuRan-yi，ZhuYing-hui，ZhouLing，ZhaoPeng，LiHong-li，ZhuLan-cai，HanHong-yu，LinHuan-xin，KangLiang，WuJiang-xue，HuangWe

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Proteins, Expression, Isolation and Analysis	… China). Annexin V-FITC/7-AAD apoptosis detection kit was from Beckman Coulter, Inc. (Marseille, France), while Double Stain Apoptosis Detection Kit (Hoechst 33342/PI) from GenScript USA Inc. (Piscataway, NJ, USA). Rabbit …	Get A Quote

摘要

Interferon-γ (IFN-γ) is regarded as a potent antitumor agent， but its clinical application is limited by its short half-life and significant side effects. In this paper， we tried to develop IFN-γ gene therapy by a replication defective adenovirus encoding the human IFN-γ (Ad-IFNγ)， and evaluate the antitumoral effects of Ad-IFNγ on nasopharyngeal carcinoma (NPC) cell lines in vitro and in xenografts model.