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Highly sensitive and noninvasive detection of epidermal growth factor receptor T790M mutation in non-small cell lung cancer.

Clin. Chim. Acta. 2013; 
HeChen，ZhengLixia，XuYuzhong，LiuMing，LiYuanguang，X
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Plasmid DNA Preparation … temperatures was measured to identify wild-type and mutant amplicons, because the fluorescence intensity depends on the QProbe dissociation from the amplicon: wild type at 59°C and mutant at 66°C. The control plasmid was prepared as follows by GenScript USA, Inc … Get A Quote

摘要

Epidermal growth factor receptor (EGFR) T790M mutation is associated with EGFR tyrosine kinase inhibitors resistance in non-small cell lung cancer (NSCLC). However， the tissue availability and technical feasibility limits the genotyping of EGFR T790M mutation in the clinical setting. The current study is， therefore， designed to develop a blood-based approach to detect the EGFR T790M mutation in advanced NSCLC patients.

关键词

EGFR，Epidermal growth factor receptor，Mutant-enriched PCR，NSCLC，Non-small cell lung cancer，Plasma，RFLP，Restriction fragment length polymorphism，Scorpion amplified refractory mutation system，Scorpions ARMS，Sequencing，T790M mutation，TKIs，Tyrosine kinase inhibi
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