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HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes.

Glia. 2014; 
NoackMonika,LeykJanina,Richter-LandsbergChrist
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Custom Vector Construction … instructed by the manufacturer. For HDAC6 knockdown, specific sequence coding for HDAC6 shRNA was cloned into pRNAT‐U6‐Hygro vector (containing GFP marker for selection; from Genscript, NJ). The shRNA sequence … Get A Quote

摘要

Histone deacetylase 6 (HDAC6) is a unique member of the HDAC family. It is localized within the cytoplasm and has unique substrate specificities for nonhistone proteins, such as α-tubulin. Furthermore, it plays a major role in protein aggregate formation and recently was demonstrated to interact with the microtubule associated protein tau and tau was identified as a possible substrate for HDAC6 in neurons. This study was undertaken to investigate whether HDAC6 is present in oligodendrocytes and whether it is involved in tubulin and tau acetylation in these cells. We show for the first time that HDAC6 is expressed in cultured rat brain oligodendrocytes. Its inhibition by the specific HDAC6 inhibitor tubasta... More

关键词

glial cells,microtubules,tau isoform expression,tauopathy,tubastatin,tubulin acetyla