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Transcriptome Analysis Reveals Novel Genes Associated with Cartilage Degeneration in Posttraumatic Osteoarthritis Progression.

Cartilage. 2019-05;

LiuChih-Chung，LeeHoong-Chien，PengYi-Shian，TsengAilun Heather，WuJia-Lin，TsaiWei-Yuan，WongChih-Shung，SuLi

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Molecular Biology Reagents	For assessment of RNA quality, RNA was electrophoresed on a 0.8% agarose gel, and ribosomal RNAs at 28S and 18S were visualized with GenScript DNAsafe nucleic acid gel stain.	Get A Quote

摘要

The current therapeutic strategy for posttraumatic osteoarthritis (PTOA) focuses on early intervention to attenuate disease progression， preserve joint function， and defer joint replacement timing. Sequential transcriptomic changes of articular cartilage in a rat model were investigated to explore the molecular mechanism in early PTOA progression.